Dopaminexxx
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Dopamine

CLINICAL USE

Treatment of dementia in mild to moderate Alzheimer’s disease

DOSE IN NORMAL RENAL FUNCTION

5–10 mg daily

PHARMACOKINETICS

  • Molecular weight                           :416
  • %Protein binding                           :95
  • %Excreted unchanged in urine     : 17
  • Volume of distribution (L/kg)       :12
  • half-life – normal/ESRD (hrs)      :70/Unchanged

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function
  • 10 to 20     : Dose as in normal renal function
  • <10           : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Unlikely to be dialysed. Dose as in normal renal function
  • HD                     :Unlikely to be dialysed. Dose as in normal renal function
  • HDF/high flux   :Unknown dialysability. Dose as in normal renal function
  • CAV/VVHD      :Unlikely to be dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugsNone known

    ADMINISTRATION

    Reconstition

    –

    Route

    Oral

    Rate of Administration

    –

    Comments

    –

    OTHER INFORMATION

    Metabolised via CYP450 3A4 and 2D6 so may interact with other drugs metabolised by these pathways



    See how to identify renal failure stages according to GFR calculation

    See how to diagnose irreversible renal disease

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